ANTIOXIDA

Although oxygen is necessary for metabolic processes in the human body, its presence has a “dark side”. Under aerobic conditions in the mitochondria of cells, carbohydrates, lipids and proteins are broken down and the energy needed for life is created. In this way, 95% of inhaled oxygen is metabolized, and the remaining 5% is converted into free radicals, the most important of which are the superoxide radical O2, hydrogen peroxide (H202) and the hydroxyl radical OH. Free radicals are not primarily harmful because they participate in the physiological processes of the body:

  • free radicals are involved in hormone synthesis
  • leukocytes use oxygen free radicals in the fight against bacteria and viruses
  • oxygen free radicals participate in the body’s natural defense against the development of cancer

Healthy cells, through their own antioxidant mechanisms, constantly maintain a finely balanced balance between the creation and elimination of oxygen free radicals; however, under the influence of physical and psychological stress, exposure to UV rays, environmental pollutants, cigarette smoke, and processed food, leads to a decrease in the cell’s detoxification capacity, resulting in “oxidative stress.” Oxidative stress facilitates the development of diseases of the heart and blood vessels, diabetes, Parkinson’s and Alzheimer’s diseases, amyotrophic lateral sclerosis, rheumatoid arthritis… and ultimately, all these diseases lead to accelerated aging of the body.

If the body’s internal capacities are exhausted, the solution is to increase the intake of proven, high-quality, synergistically balanced natural antioxidants – ENGRIA ANTIOXIDA – spirulina extracts of grapes and corn seeds, green tea, goji berries, alpha lipoic acid, vitamins (vitamins C, E, D), minerals (selenium, calcium, zinc, chromium, copper).

  • Spirulina: is a microalgae that is considered the “super food of the 21st century” because it contains vitamins of the B group (B1, B2, B12, folic acid); vitamins A, C, D, K; minerals (iron, copper, magnesium, calcium, potassium, sodium, zinc, selenium, manganese); beta carotene (whose concentration in spirulina is 10 times higher than in carrots). However, the most important ingredients of spirulina are zeaxanthin, which has a protective effect on the nervous system and eyes and protects cells from free radicals and oxidative stress, and phytocyanin, which has an anti-inflammatory role. Thanks to all the ingredients, the ORAC value (Oxygen Radical Absorbance Capacity) of spirulina is about 6.0 µmol TE/100g, which is a higher value compared to, for example, to blueberries. All ingredients have a positive effect on: regulating the level of glucose and glycosylated hemoglobin in the blood, lowering elevated levels of triglycerides and bad LDL cholesterol, with an increase in the level of good HDL cholesterol and prevention of cholesterol oxidation. Spirulina also helps lower blood pressure, promotes physical endurance and removes muscle fatigue (contains 22 essential amino acids), improves liver and bile function, strengthens immunity, helps in the treatment of rheumatoid arthritis, has an anticarcinogenic effects, protects cells from the negative effects of heavy metals (lead, mercury, arsenic)
  • Grape seed extract: contains high concentrations of vitamin E, flavonoids, linolenic acid and an antioxidant-an oligomeric proanthocyanidin complex recommended for the treatment of Alzheimer’s disease, diabetes, cardiovascular disease, improves night vision, protects collagen and slows aging
  • Green tea extract: contains antioxidants, the most significant of which are phenolic acid and catechins. Catechins from green tea belong to the flavonoid family, which are powerful antioxidants and free iron scavengers. Among the catechins, EGCG (epigallocatechin-3-gallate) stands out, of which Antioxida even contains 45%. EGCG has antioxidant and anti-inflammatory effects, improves the function of the cardiovascular system (lowers the level of bad LDL cholesterol, lowers blood pressure, reduces inflammatory elements – tumor necrosis factor and CRP). EGCG also has a positive effect in the treatment of neurodegenerative brain diseases (Alzheimer’s and Parkinson’s diseases), because its antioxidant and anti-inflammatory properties can reduce oxidation and death of brain cells and accelerate the regeneration of neurons. EGCG may help reduce the production of the beta amyloid protein associated with Alzheimer’s disease. EGCG achieves its positive effects when normalizing the level of glucose and insulin in the blood and helps in the process of losing weight
  • Goji berries: are considered a “superfood” because they contain 19 amino acids (of which 8 are essential), 21 trace minerals, including anticarcinogenic germanium,; B vitamin complex along with vitamin C and E; essential fatty acids; cyperone, which lowers blood pressure and relieves PMS symptoms; solavetivon – a strong antifungal and antibacterial strain; betaine, which the liver uses to produce choline, which improves memory; beta-carotene, zeaxanthin, beta-sitosterol, which lowers cholesterol levels, improves sperm quality and sperm motility, and raises testosterone levels
  • Corn seed extract: contains significant amounts of minerals (copper, phosphorus, manganese, potassium and zinc) necessary for proper tissue growth and development, functioning of enzymatic and hormonal processes; vitamins B3, B5, B6 and B9 and antioxidants – ferulic acid, anthocyanin, lutein, zeaxanthin, which contributes to the prevention of diseases of the eyes and digestive system, as well as the treatment of anemia and the lowering of blood pressure and homocysteine levels
  • Alpha lipoic acid: has antioxidant, anti-inflammatory, anticarcinogenic and antimutagenic effects. Its power in the regeneration of vitamin C and fat-soluble vitamins, which leads to the acceleration of the metabolism of fats and carbohydrates, is particularly noteworthy, therefore it has found its application especially in the protection of the liver, in the case of damage to the nervous system, Alzheimer’s disease, multiple sclerosis, type II diabetes and diabetic polyneuropathy, but also for the regulation of hyperlipidemia and the treatment of glaucoma
  • Beta carotene (provitamin of vitamin A): is recognized as an anticancer agent, and is important for the normal function of macrophages and lymphocytes (cells of the body’s defense system), in preventing damage caused by sunlight and in preventing skin cancer
  • Vitamin C: plays an important role in oxidation-reduction processes in the body, affects the exchange of carbohydrates, proteins and cholesterol. The primary function of vitamin C is production of collagen, a protein necessary for building connective tissue in the skin, ligaments and bones. It helps with bacterial infections and is a natural antioxidant
  • Vitamin E (d-alpha tocopherol): is necessary for maintaining a strong immune system and protects the thymus and leukocytes from oxidation, is necessary for proper development of the retina, and at the same time protects against cataracts and macular degeneration. It participates in the normal functioning of the gonads and the nervous system, and achieves its antioxidant effect by preventing the oxidation of fatty acids
  • Vitamin D: helps prevent osteoporosis, contributes to the prevention of diseases of the heart and blood vessels, and has a positive effect on the development of the nervous and immune systems. Among its most important functions is the slowing down of aging because it reduces the number of changes in the DNA molecule, i.e. it prevents telomere shortening
  • Selenium (L-selenomethionine): contributes to the normal function of the immune system, normal spermatogenesis, maintaining the quality of hair and nails, and protects cells from oxidative stress. Although it is premature to call selenium a nutrient that guarantees longevity, the results of numerous studies show that this essential element plays an important role in maintaining the health of the elderly population. In addition to reducing mortality from cancer, good selenium status can protect older people from muscle weakness and cognitive decline
  • Chromium: is a mineral that helps regulate glucose and insulin levels, improves lipid levels, and has a positive effect on bone health and cognitive function

Although we cannot avoid oxidative stress, the synergistic effect of natural antioxidants ENGRIA – ANTIOXIDA, aids in the fight against it by preventing the development of chronic diseases, which eventually leads to the slowing of the aging process and the restoration of health to our years.

ANTIOXIDA

A dietary supplement that acts as an antioxidant and provides protection against the effects of the sun’s rays.

References:

  1. Matschke V, Theiss C, Matschke J. Oxidative stress: the lowest common denominator of multiple diseases. Neural Regen Res. 2019 Feb;14(2):238-241.
  2. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative Stress and Antioxidant Defense. World Allergy Organ J. 2012 Jan; 5(1): 9–19.
  3. Harman, D. Antioxidant supplements. Effects on disease and aging with United States population. J. Amer. Aging. Assoc. 2000. 23, 25-31.
  4. Shih CM, Cheng SN, Wong CS, Kuo YL, Chou TC. Antiinflammatory and antihyperalgesic activity of C-phycocyanin. Anesth Analg. 2009; 108(4):1303-10.
  5. Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress – Lu HK, Hsieh CC, Hsu JJ, Yang YK, Chou HN. European Journal of Applied Physiology. 2006; 98(2):220-6.
  6. Cascella M, Bimonte S, Muzio MR et al. The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer’s disease: an overview of pre-clinical studies and translational perspectives in clinical practice. Infect Agent Cancer. 2017;12:36 doi:1186/s13027-017-0145-6
  7. Mak J.C. Potential role of green tea catechins in various disease therapies: Progress and promise. Clin. Exp. Pharmacol. Physiol. 2012;39:265–273. doi: 10.1111/j.1440-1681.2012.05673.x.
  8. Moon Hw, Park JW, Lee KW et al. 11. Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model. World J Mens Health.2017 35 (1): 43-50. doi:5534/wjmh.2017.35.1.43
  9. Speer H, D’Cunha N, Alexopoulos NI et al. Anthocyanins and Human Health—A Focus on Oxidative Stress, Inflammation and Disease. Antioxidants (Basel) 2020; 9(5):366 doi:3390/antiox9050366
  10. Vallianou N, Evangelopoulos A, Koutalas P. Alpha-Lipoic Acid and Diabetic Neuropathy. Rev Diabet Stud.2009. 6(4): 230.36.doi:1900/RDS.2009.6.230
  11. Mazidi M, Michos ED, Banach M. The association of telomere length and serum 25-hydroxyvitamin D levels in US adults: the National Health and Nutrition Examination Survey. Arch Med Sci.2017. 13(1): 61-5. doi:5114/aoms.2017.64714
  12. Duntas LH, Benvenga S 2015 Selenium: an element for life. Endocrine 48:756–775
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